CareLit Fachartikel
Human ES cell-derived neurons recapitulate endogenous fiber projections upon transplantation into the adult rodent brain
JA Steinbeck, P Koch, O Brüstle · Aktuelle Neurologie · 2007 · Heft 09
Dokument
1137144
CareLit-ID
Jahr
2007
Publikation
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Metadaten
DOI
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Zusammenfassung
The potential of neural grafts to replace adult brain tissue in a structurally and functionally relevant way is an essential prerequisite for reconstructive approaches. While numerous studies have focused on the controlled derivation of neuronal subtypes from human ES cells, the ability of these in vitro generated neurons to innervate the host CNS has remained largely unexplored. To evaluate the potential of human ES cell-derived neurons to differentiate and grow projections in the adult brain, micrografts were stereotactically targeted at the primary motor cortex or the hippocampus of rodents. Most donor neuron…
Schlagworte
Transplantation
Axons
After
Capsula interna
Corpus Callosum
Basal Ganglia
Dentate Gyrus
Tumor
Aktuelle Neurologie
