Pathoanatomic correlates of psychiatric symptoms in PINK1 mutation carriers
K Reetz, R Lencer, S Steinlechner, C Gaser, J Hagenah, C Büchel, A Djarmati, HR Siebner, C Klein, F Binkofski · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objectives: Mutations in the PINK1 gene can cause parkinsonism and are frequently associated with psychiatric symptoms that may even precede motor symptoms and signs. The aim of the present voxel-based morphometric (VBM) MRI study was to determine whether different psychiatric symptoms in PINK1 mutation carriers (Pmc) are associated with specific structural gray matter volume (GMV) changes. Methods: We compared structural MR images of 14 Pmc (major depression [N=5], schizophrenia-spectrum disorders [N=4], panic disorder [N=2], adjustment disorder [N=2] and obsessive compulsive personality disorder [N=2]) and 14…
