Effectiveness of topiramate in patients with epilepsy transitioning from carbamazepine or oxcarbazepine – results of an open-label, non-interventional trial

Objective: To explore seizure frequency and tolerability in patients with epilepsy treated with topiramate (TPM; Topamax®) transitioning from carbamazepine (CBZ) or oxcarbazepine (OXC). Methods: Multicenter open-label non-interventional trial (TOPMAT-EPY-405) prospectively following patients with epilepsy ≥12 years of age who were previously unsuccessfully treated with CBZ (72.1%) or OXC (27.9%) for 26 weeks after transitioning to TPM. A 12-week retrospective seizure frequency was used as baseline. Results: 140 patients (54% female; mean (±SD) age 47±18 years) were enrolled. 72.1% of patients had unsuccessfully…