The pharmacokinetics of alcohol for essential tremor

Objective: We investigated the time course of the effect of alcohol on tremor characteristics in 10 patients with essential tremor (ET). Methods: The dosage of alcohol was adapted for each individual according to weight and sex to receive a target response of ˜0.8‰ blood alcohol level. The postural tremor amplitude at the wrist was recorded using an accelerometer placed on the dorsum of the hand. Tremor recordings, a modified Fahn-scale, the visual analogue-scale (VAS), Archimedes spirals and blood alcohol were measured at baseline and at 10, 20, 30, 40, 50, 60, 90 minutes, in the evening and the next morning af…