Induction of fibril-like beta-amyloid aggregates by a natural substance decreases soluble oligomers and protects from neurotoxicity

Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease belong to the group of brain amyloid disorders and involve the formation and accumulation of misfolded disease-specific proteins. According to the amyloid cascade hypothesis, accumulation of the amyloid-beta peptide(A-beta) is central for the pathogenesis of Alzheimer's disease. Increasing evidence suggests that soluble precursor aggregates such as oligomers rather than insoluble amyloid fibrils are responsible for synaptic dysfunction, axonal and dendritic degeneration, and neuronal death. Reducing the prevalence of the toxic aggregate species r…