Cytotoxic T-lymphocyte antigen-4 haplotypes and T cell activation in irritable bowel syndrome
T Liebregts, B Adam, C Bredack, S Lester, S Downie-Doyle, SM Brierley, M Gururatsakul, KR Pilkington, NJ Talley, G Holtmann · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Immune activation may play a role in a subgroup of Irritable Bowel Syndrome (IBS). We have recently shown that PBMC- mediated cytokine secretion is significantly enhanced in IBS (Gastroenterology 2007; 132:913–920). This may reflect an impaired down-regulation of immune function. The cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a negative signal for regulatory T-cell activation and the +49GA and the CT60A/G polymorphisms are known to be associated with immune-mediated diseases. We hypothesized that a CTLA-4 haplotype is associated with enhanced T cell activation and symptom pattern in IBS. Aim: Thus we aim…
