CareLit Fachartikel
Limitations of two TCA's serotonergic effects on visceral nociception in a rat model
L Bechmann, J Best, K Leineweber, G Holtmann, G Gerken · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Dokument
1137200
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Jahr
2007
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Zusammenfassung
Aims: Tricyclic antidepressants (TCA) like amitriptyline (AM) or desipramine (DE) are established drugs in the treatment of abdominal pain in IBS patients. Their serotonergic properties are assumed to be responsible for this effect. Clinical data suggests that SSRIs have lower potential in treating those symptoms. Thus, we postulate that the heterogeneity of TCA's effects plays a crucial role in their efficacy on visceral pain. Aims: We aim to characterize the influence of two TCAs on visceral nociception. Reserpine (RS) was used to antagonize TCA's sertonergic actions in order to discriminate these effects from…
Schlagworte
5-HT
Abdominal Pain
Abdominal Wall
Amitriptyline
Desipramine
Zeitschrift für Gastroenterologie
