IL23R variants are associated with inflammatory bowel disease in the German population
J Glas, J Seiderer, M Wetzke, A Konrad, HP Török, S Schmechel, L Tonenchi, C Grassl, J Dambacher, S Pfennig, K Maier, T Griga, W Klein, J Epplen, U Schiemann, C Folwaczny, P Lohse, B Göke, T Ochsenkühn, B Müller-Myhsok, M Folwaczny, T Mussack, S Brand · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background/aim: Recently, the IL-23R gene has been identified as disease susceptibility gene for inflammatory bowel disease (IBD) in the North American population. The aim of our study was to test this association in a large German IBD cohort. Methods: Genomic DNA from 2313 Caucasian individuals including 723 patients with Crohn's disease (CD), 400 patients with ulcerative colitis (UC), and 1190 healthy unrelated controls was analyzed for ten different IL23R SNPs (rs1004819, rs7517847, rs10489629, rs2201841, rs11465804, rs11209026, rs1343151, rs10889677, rs11209032, rs1495965). Genotyping was performed on a Ligh…
