BAX mutations are associated with an adverse prognosis in Lynch syndrome-associated colorectal cancer
K Schulmann, S Özdemir, M Helwing, C Pox, S Stemmler, E Kunstmann, SA Hahn, J Willert, A Tannapfel, A Reinacher-Schick, W Schmiegel · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Lynch syndrome-associated colorectal cancer (CRC) is associated with a favorable prognosis compared to sporadic CRC, yet prognostic factors for Lynch syndrome-associated CRC are poorly investigated. We analyzed 70 colorectal neoplasms with high levels of microsatellite instability from 65 patients for frameshift mutations in the coding regions in the TGFBR2, ACVR2, BAX, MSH3, MSH6, AIM2, SEC63L genes as well as for P53 overexpression and loss of SMAD4 expression. In order to minimize selection bias, we restricted the evaluation of the prognostic value to 45 patients in whom MSI testing was initiated within 6 mon…
