TGF-beta induces IL–15 in hepatocytes: A potential new role for IL–15 in liver disease
P Godoy, E Bulanova, HL Weng, A Bachmann, E Üeberham, S Bulfone-Paus, S Dooley · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Liver fibrogenesis is a process involving a complex interaction of cellular components. We recently described a new role for hepatocytes in the process of fibrogenesis, in which TGF-β induces expression and secretion of CTGF, another potent profibrogenic cytokine. Interleukin–15 has emerged as a new player in several models of liver damage, but its precise role has not yet been determined. Real Time PCR showed that TGF-β induces IL–15 mRNA up to 80 fold in primary mouse hepatocytes, and up to 10 fold in AML12 cells. Using chemical inhibitors, we determined that, although ALK–5 activity is essential, ERK and JNK…
