Upregulation of AT1 Receptor in MDR2 Knockout Mice after low dose antifibrotic therapy with Telmisartan
S Schulte, I Strack, M Odenthal, V Mezger, HP Dienes, T Goeser, U Töx, HM Steffen · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Angiotensin II stimulates liver fibrosis and cell proliferation via angiotensin II receptor type 1 (AT1R). In advanced liver disease, AT1R expression is increased on, among other cell types, bile duct epithelial cells, but in total AT1 R expression is downregulated. The biliary excretion of the AT1R blocker telmisartan may, therefore, argue for a positive impact of this substance on the course of chronic cholestatic liver disease. We examined the antifibrotic efficacy of telmisartan in MDR2 knockout mice, a well-established animal model of progressive cholestasis mimicking primary sclerosing cholan…
