CareLit Fachartikel
Steatosis sensitizes hepatocytes to bile acid-induced apoptosis in a human in vitro model
T Pusl, N Wild, R Wimmer, T Vennegeerts, C Rust · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Dokument
1137521
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Jahr
2008
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Zusammenfassung
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the Western world and can progress to liver cirrhosis. Palmitic (C16: 0) and oleic (C18: 1) acids are the most abundant fatty acids (FFA) in livers of patients with NAFLD. Hepatocellular apoptosis is a potentially important mechanism of liver injury and has been shown to be increased in patients with NAFLD. Since the role and the mechanisms of hepatocellular apoptosis in NAFLD remain unclear, we aimed to test the hypothesis if steatosis sensitizes hepatozytes to apoptosis induced by low concentrations of the major hu…
Schlagworte
Apoptosis
free fatty acids
liver
steatosis
Cholestasis
Caspase 3
After
Zeitschrift für Gastroenterologie
