Taurolithocholic acid–3 sulfate impairs insulin signaling
G Mannack, D Graf, MM Donner, L Richter, B Görg, S vom Dahl, D Häussinger, F Schliess · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Insulin resistance is a widespread condition in cholestatic liver disease, however, the impact of bile acids on hepatic insulin signaling is unknown. Here, the effect of taurolithocholic acid–3 sulfate (TLCS) on insulin signaling was studied in cultured rat hepatocytes and perfused rat liver. TLCS induced insulin resistance at the level of insulin receptor (IR)beta Tyr(1158) phosphorylation, insulin receptor substrate 1-associated phosphoinositide (PI) 3-kinase activity and protein kinase (PK)B Ser(473) phosphorylation in cultured hepatocytes. Consistently, the insulin stimulation of the PI 3-kinase-dependent K+…
