Evolution of naturally occurring Hepatitis B Virus Test and Immune Escape mutations facilitating persistence and symptomatic viral flare in an HIV-coinfected patient
S Amini-Bavil-Olyaee, C Henke-Gendo, D Challapalli, C Trautwein, A Heim, F Tacke · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Due to its high rate of naturally occuring mutations, Hepatitis B Virus (HBV) is able to adapt rapidly to selective pressures. Mutations in the immunodominant A-determinant domain of the HBsAg are usually associated with immunoglobulin or vaccine administration. We identified an HIV-coinfected, chronically HBV-infected patient who tested HBsAg negative and developed an acute hepatitis associated with an HBV flare. Methods: Sequential HBsAg-ELISA test escape isolates obtained before and during a flare of hepatitis in an HIV coinfected patient who tested negative for the HBsAg were analysed for their genotyp…
