Neuronal correlates of movement disorders in normal pressure hydrocephalus (NPH)-before and after therapeutic lumbar puncture
M Ebke, E Küstermann, B Neubauer, G Schwendemann, M Herrmann, D Leibfritz · Klinische Neurophysiologie · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: Normal pressure hydrocephalus (NPH) affects predominantly elderly people possing major impact gait problems which improve upon guidance. Objective and Hypothesis: It has been hypothesised that reduced resorption of CSF leads to penetration into the frontal reducing the cerebral blood flow (CBF). We document blood-oxygen level dependend (BOLD)-signal changes with functional magnetic resonance imaging (fMRI) before and after lumbar puncture (LP). In order to explore the neuronal correlates, subjects were asked to perform imaginary foot movement and walking tasks. We expected a changed brain activity…