NO synthase isoforms are involved in the LPS-induced alteration of hypoxic vasoconstriction
B Egemnazarov, S Wehner, C Schudt, C Hesslinger, H Ghofrani, R Schermuly, W Seeger, F Grimminger, N Weißmann · Pneumologie · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: Acute lung injury (ALI), is clinically characterized by diffuse pulmonary infiltrates, severe hypoxemia, and disturbed control of vascular tone. Augmentation as well as attenuation of hypoxic pulmonary vasoconstriction (HPV) has been described in ALI. To better understand the potential role of iNOS and eNOS in this pathological process we used a rabbit model of LPS-induced alteration of hypoxic vasoconstriction combined with exposure to periodic hypoxia. Methods: In the model of isolated perfused rabbit lung we performed repetitive hypoxic maneuvers with 3% O2 (10min) interrupted by 15min of normoxic…
