CareLit Fachartikel
Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model for the metabolic syndrome
T Dreja, Z Jovanovic, A Rasche, R Kluge, R Herwig, HG Joost, G Yeo, H Al-Hasani · Diabetologie und Stoffwechsel · 2008 · Heft 04
Dokument
1137910
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Jahr
2008
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Zusammenfassung
Aims: NZL mice develop a polygenic disease pattern of obesity, hyperglycaemia and hyperinsulinemia which resembles the human metabolic syndrome. The prevalence for type-2 like diabetes is greatly increased in animals receiving a high-fat diet (HFD). However animals fed with a carbohydrate-free high fat-diet (CHFD) were protected from developing diabetes. In the present study NZL mice were fed HFD or CHFD and body weight, body fat and blood glucose were measured weekly. We observed that on both diets the animals became equally obese (˜ 55g) and glucose intolerant. However, even after wk 22 animals on CHFD were no…
Schlagworte
Diet
Blood Glucose
Association
Obesity
Blood
After
Diabetologie und Stoffwechsel
