Glucose-dependent insulinotropic polypeptide (GIP) modulates inflammatory markers and regulates proliferation in subcutaneous adipose tissue
Ö Gögebakan, S Mosig, I Middelbeck, F Isken, N Rudovich, MA Osterhoff, AFH Pfeiffer · Diabetologie und Stoffwechsel · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is secreted in response to food intake and modulates β-cell function. GIP acts on various tissues, including pancreatic β-cells, via interaction with its G-protein-coupled receptor. Some studies in rodents suggested that GIP directly links overnutrition to obesity. GIP exerts a physiological role on lipid uptake into adipocytes. Insulin release by GIP is contingent upon elevated blood glucose similar to the other important incretin hormone, glucagon like peptide 1 (GLP-1). This assures that insulin release is not stimulat…
