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KLF11 differentially regulates PDX1-induced activation of the human insulin promoter in rodent beta cells and human non beta cells

N Perakakis, G Päth, X Niu, S van Loosen, M Alt, T Stahl, J Seufert · Diabetologie und Stoffwechsel · 2008 · Heft 04

Dokument
1137930
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
N Perakakis, G Päth, X Niu, S van Loosen, M Alt, T Stahl, J Seufert
Ausgabe
Heft 04 / 2008
Seiten
–
Erschienen: 2008-04-18 00:00:00
ISSN
1861-9002
DOI
10.1055/s-2008-1076418

Zusammenfassung

Aims: KLF11 is a pancreas enriched member of the Sp1/KLF transcription factor family which plays an important role in mammalian gene regulation. Previously we demonstrated that human (h)KLF11) inhibits human insulin promoter (hInsP) activity in rodent beta cell lines via an unknown mechanism. Here we present results from ongoing experiments in which we test the hypothesis that KLF11 interferes with the major hInsP transactivator PDX1. Methods: We performed transient cotransfections of INS-1E and beta-TC3 beta cells and HEK293 non beta cells with hInsP-controlled SEAP (secreted alcaline phosphatase) reporter plas…

Schlagworte

Hinsp Klf11 Cells Activity About Fragments Activation Human Inhibits Results 881Hinsp Stimulates Diabetologie und Stoffwechsel