Elevated Cord Blood Levels of Mannose-Binding Lectin-Associated Serine Protease-2 (MASP-2) in Infants with Necrotizing Enterocolitis – a Case-Control Study
LJ Schlapbach, C Aebi, U Fisch, R Ammann, M Otth, S Bigler, M Nelle, S Berger, U Kessler · Zeitschrift für Geburtshilfe und Neonatologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: While the general prognosis for premature infants has improved in recent years, morbidity and mortality due to necrotizing enterocolitis (NEC) remain high. Several innate immunity polymorphisms have been proposed to explain susceptibility to NEC, but the data are conflicting. Mannose-binding lectins (MBL) are soluble pattern-recognition receptors that bind MBL-associated serine protease-2 (MASP-2), thereby activating the complement system by the so-called lectin-pathway. Deficiency of either MBL or MASP-2 due to single nucleotide polymorphisms is common. While MBL deficiency has been associated with…
