Characterization of a new acute necrotizing pancreatitis model induced by L-ornithine
G Biczó, P Hegyi, S Dósa, B Iványi, K Jármay, Z Hracskó, I Varga, A Varró, J Lonovics, I Gukovsky, A Gukovskaya, S Pandol, T Takács, Z Rakonczay Jr · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Intraperitoneal (i.p.) administration of large doses of L-arginine is known to induce severe acute pancreatitis in rats, although the exact pathomechanism is unknown. L-arginine is metabolized via numerous different pathways. Two key enzymes that are involved in this process are nitric oxide (NO) synthase (which catalyzes the formation of NO and L-citrulline) and arginase (which produces L-ornithine and urea). The aim of the present study was to establish whether metabolites of L-arginine (L-ornithine, L-citrulline and NO) cause pancreatitis. Methods: Male Wistar rats were injected with L-ornithine, L-citrulline…
