CareLit Fachartikel
Elevated endocannabinoid levels in liver fibrosis are driven by diminished hepatic expression and activity of endocannabinoid degrading enzymes
SV Siegmund, A Wojtalla, F Herweck, A Zimmer, MV Singer · Zeitschrift für Gastroenterologie · 2010 · Heft 01
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1138270
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Jahr
2010
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Zusammenfassung
Aims: We and others have previously shown, that the hepatic endocannabinoid (EC) system becomes activated during fibrogenensis. In particular, the expression of cannabinoid receptors and levels of ECs (anandamide, AEA; 2-arachydonoyl glycerol, 2-AG) are upregulated. However, the mechanisms that lead to the increased levels of ECs during liver fibrogenensis are unknown. AIM: We sought to analyse the hepatic expression and activity of the major AEA-degrading enzyme fatty acid amide hydrolase (FAAH) and the 2-AG-degrading enzyme monoacyl glycerol lipase (MGL) in normal and fibrotic mouse livers at different timepoi…
Schlagworte
Liver fibrosis
endocannabinoids
fatty acid amide hydrolase
monoacyl glycerol lipase
After
Chromatography
Amide
Lead
Zeitschrift für Gastroenterologie
