Proteasome inhibition during oncolytic infection improves antitumoral immunity and inhibits metastatic growth of HCC
B Boozari, B Mundt, N Woller, E Gürlevik, P Schache, M Manns, S Kubicka, F Kühnel · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Infection of a dying cell by a pathogen dictates the immune response against intracellular antigens, but the impact of tumor cell death during oncolytic viral infection on the induction of antitumoral immunity is unknown. Recently, ER-stress due to disruption of the unfolded-protein-response (UPR) has been implicated in the bypass of immune tolerance mechanisms. Since viruses and proteasome inhibitors both induce accumulation of misfolded proteins, we investigated ER-stress mediated apoptosis and antitumoral immune responses in mouse models of hepatocellular carcinoma after treatment with the proteasome inhibito…
