Systemic spreading of intraperitoneal Staphylococcus aureus is increased in experimental liver cirrhosis but unaltered by splanchnic sympathectomy
K Knebel, M Worlicek, HJ Linde, L Moleda, R Straub, E Gäbele, C Hellerbrand, J Schoelmerich, R Wiest · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
In liver cirrhosis, nosocomial spontaneous bacterial peritonitis (SBP) is associated with poor prognosis and most frequently caused by gram-positive bacteria. We previously reported that the well-known hyperactivity of the sympathetic nervous system (SNS) in advanced cirrhosis contributes to the translocation of E. coli from the peritoneum to mesenteric lymph nodes and extraintestinal sites. However, the role of splanchnic SNS-activity for spreading of gram-positive challanges in cirrhosis remains unclear. Methods: Staphylococcus aureus (S. aureus 106 CFU/ml) was given i.p. (3ml) and 6 hours later mesenteric lym…
