CareLit Fachartikel

Elevated expression of the FBP-interacting repressor (FIR) induces FBP-1 and supports proliferation and migration of HCC cells

M Malz, M Bissinger, S Singer, T Longerich, P Schirmacher, K Breuhahn · Zeitschrift für Gastroenterologie · 2010 · Heft 01

Dokument
1138276
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Malz, M Bissinger, S Singer, T Longerich, P Schirmacher, K Breuhahn
Ausgabe
Heft 01 / 2010
Seiten
–
Erschienen: 2010-01-12 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1246428

Zusammenfassung

Aims: We have recently demonstrated that overexpression of the transcription factor far upstream element (FUSE) binding protein (FBP)-1 induces hepatocellular carcinoma (HCC) cell proliferation by partly employing the microtubule-modifying factor stathmin/oncoprotein-18 [1, 2]. Since the FBP-interacting repressor (FIR) efficiently inhibits FBP-1 in vitro, we hypothesized that FIR expression is abolished or reduced in HCC cells in order to facilitate protumorigenic FBP-1 activity. Methods: Expression of four different FIR splice variants were analyzed in human normal liver, premalignant lesions, and hepatocellula…

Schlagworte

FBP-interacting repressor far upstream element binding protein hepatocellular carcinoma stathmin/oncoprotein-18 After Zeitschrift für Gastroenterologie