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Enhanced generation of carcinogenic DNA lesions in rats fed a high fat choline, methionine deficient diet
H Qin, G Millonig, VU Buko, S Mueller, HK Seitz · Zeitschrift für Gastroenterologie · 2010 · Heft 01
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1138277
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Jahr
2010
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Zusammenfassung
Aims: Obese insulin deficient, Leptin deficient Zucker rats (fa/fa) develop spontaneously metabolic syndrome and fatty liver. It has been shown that obese Zucker rats exhibited increased hepatic oxidative stress and showed a significant increase in carcinogenic exocyclic etheno-DNA adducts as compared to their lean littermates (Wang et al., Hepatology 50,453: 2009). Therefore, we wondered whether such an effect could also be observed in an animal model in which steatosis is induced by diets and which resembles better the human situation. Methods: In the present study male Wistar rats received a semi-synthetic hi…
Schlagworte
cytochrome P450 2E1
etheno DNA adducts
oxidative stress
Diet
Adiponectin
Cholesterol
Choline
After
Tumor
Zeitschrift für Gastroenterologie
