Tumor vaccination during oncolytic inflammation leads to regulatory T cell-dependent virus/tumor immune interference that facilitates effective cancer immunotherapy
N Woller, B Mundt, E Gürlevik, M Manns, L Zender, T Wirth, F Kühnel, S Kubicka · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
A balance between effector and suppressor mechanisms dictates whether an infection would overcome tolerance mechanism to trigger autoimmunity. In order to shift this balance in favor of antitumoral immunity we performed vaccinations with tumor-antigen loaded dendritic cells before, during or after oncolytic inflammation of a primary tumor. We observed a strongly enhanced antitumoral CD8+ T cell immune response which was accompanied by inhibition of the antiviral humoral immune response and a shift to Th2-immunoglobulin isotype, when DC vaccination was performed at the time of oncolytic inflammation. This interfe…
