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New autoantibodies in primary sclerosing cholangitis: reactivity with distinct immunodominant epitopes of sulfite oxidase

BE Preuß, C Berg, F Altenberend, M Gregor, S Stevanovic, R Klein · Zeitschrift für Gastroenterologie · 2010 · Heft 01

Dokument
1138286
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
BE Preuß, C Berg, F Altenberend, M Gregor, S Stevanovic, R Klein
Ausgabe
Heft 01 / 2010
Seiten
–
Erschienen: 2010-01-12 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1246528

Zusammenfassung

From preliminary data we had evidence that sera from patients with cholestatic liver diseases react with an antigen fraction prepared from chicken liver containing sulfite oxidase (SO). In order to analyze this reactivity in more detail, we produced human recombinant SO, and it will be shown, that anti-SO antibodies are confined to primary sclerosing cholangitis (PSC). Human recombinant SO was expressed in E. coli. Sera from 16 untreated PSC-patients, 149 patients with primary biliary cirrhosis (PBC) or autoimmune hepatitis (AIH), and 73 patients with inflammatory bowel diseases (IBD) were investigated by ELISA…

Schlagworte

primary sclerosing cholangitis autoantibodies sulfite oxidase Antibodies Cholangitis Autoimmune Hepatitis Hepatitis Zeitschrift für Gastroenterologie