The hepatic ABCB4 transporter for phosphatidylcholine as novel modulator of glucose homoestasis
K Hochrath, M Krawczyk, M Mahler, B Rathkolb, K Butuzova, M Acalovschi, H Fuchs, V Gailus-Durner, E Wolf, M Hrabé de Angelis, F Lammert · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
The human chromosome 7q21–31 region is regarded to be linked to quantitative traits of the metabolic syndrome and glucose metabolism. Herein we analyse a mouse model and two human cohorts to assess a potential role of the gene encoding the phosphatidylcholine (PC) transporter ABCB4 located in this chromosomal region in glucose homoestasis. We analysed FVB/NJ and BALB/cJ Abcb4 knockout and control mice at 15 weeks of age at the German Mouse Clinic1. After fasting, we performed intraperitoneal glucose tolerance tests (IpGTT). Otherwise, liver enzyme activities and plasma glucose levels in unfasted mice were determ…
