CareLit Fachartikel

Evaluation of Bioluminescence Imaging for Monitoring of Pneumococcal Disease Progression in Mice

S Henken, J Bohling, T Welte, UA Maus · Pneumologie · 2010 · Heft 01

Dokument
1138296
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
S Henken, J Bohling, T Welte, UA Maus
Ausgabe
Heft 01 / 2010
Seiten
–
Erschienen: 2010-01-20 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0029-1247918

Zusammenfassung

Aims: Bioluminescence imaging is an innovative, non-invasive tool to analyze disease progression in the absence or presence of specific therapeutic interventions under real-life conditions in small laboratory animals. Methods/Results: In this study, we evaluated bioluminescence imaging as a tool to monitor pneumococcal disease progression in two mouse strains (BALB/c, C57BL/6) in response to infection with different serotypes of Streptococcus pneumoniae. Longitudinal bioluminescence imaging of pneumococcal disease progression provided excellent correlations with bacterial loads in BALB/c mice challenged with inv…

Schlagworte

Imaging Bioluminescence Pneumococcal Disease Progression Bacterial Loads Pneumoniae Mouse C57Bl Correlations Serotype Pneumologie