Local reactivation of memory T cells results in infiltration of eosinophils and neutrophils into the airways – a mouse model for severe asthma?

Einleitung: Asthma is one of the most common chronic inflammatory diseases affecting more than 300 Million people worldwide. Globally, the economic burden associated with asthma exceeds those of HIV/AIDS and tuberculosis together annually producing direct medical and indirect costs of ca. €18 Billion for Europe alone. Remarkably, the economic burden of asthma disproportionally affects those with the most severe form of the disease. Even though patients with severe asthma represent just 10% of all asthmatics, they account for more than 50% of all direct and indirect costs. The high amount of costs is based on the…