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Natalizumab and regulation of cerebral blood flow: results from an observational study

M Reinhard, B Rosengarten, L Kirchhoff, A Hetzel, S Rauer · Klinische Neurophysiologie · 2010 · Heft 03

Dokument
1138467
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
M Reinhard, B Rosengarten, L Kirchhoff, A Hetzel, S Rauer
Ausgabe
Heft 03 / 2010
Seiten
–
Erschienen: 2010-03-02 00:00:00
ISSN
1434-0275
DOI
10.1055/s-0030-1250868

Zusammenfassung

Aims: Natalizumab inhibits adherence of leukocytes to the cerebral endothelium. Leukocytes play a role in regulating the vascular tone. Natalizumab may thus also affect cerebral vasoregulation. This observational study investigates whether neurovascular coupling and cerebral autoregulation are altered after routine clinical infusion of natalizumab in patients with relapsing remitting multiple sclerosis. Methods: In eighteen patients receiving a regular infusion of 300mg natalizumab, neurovascular coupling to visual stimulation (control system approach) and dynamic cerebral autoregulation (phase and gain of 0.1Hz…

Schlagworte

After Autoregulation Observational Study Blood Posterior Cerebral Artery Blood Flow Velocity Affect Klinische Neurophysiologie