Navigated multimodal presurgical evaluation of motor representations in patients with perirolandic tumors

The aim of this cross-sectional study was to investigate neural plastic strategies in patients with perirolandic tumors. The question was if patients with perirolandic tumors exhibit changes in the motor representation of the affected hemisphere that correlates with their functional deficit. Transcranial magnetic stimulation (TMS) can supply direct evidence about activity in cortical circuitry. Navigated-TMS (nTMS) supplies further information about the location and spatial extent of a motor representation. This information can be confounded by the problem of multiple local maxima. To address this problem we int…