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Type I IFNs mediate innate intracellular defense to Legionella pneumophila

J Lippmann, H Müller, V van Laak, S Shin, G Taylor, N Suttorp, C Roy, B Opitz · Pneumologie · 2010 · Heft 03

Dokument
1138505
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
J Lippmann, H Müller, V van Laak, S Shin, G Taylor, N Suttorp, C Roy, B Opitz
Ausgabe
Heft 03 / 2010
Seiten
–
Erschienen: 2010-03-01 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0030-1251248

Zusammenfassung

Legionella pneumophila is an intracellular pathogen which can cause severe pneumonia called Legionnaires' disease. Host innate immune responses to L. pneumophila depend on (I) the Toll-like receptors, (II), the NAIP5/IPAF inflammasome and (III) IFNγ-mediated antibacterial mechanisms. In our study we investigate a further innate defense mechanism potentially directed against Legionella infection, which is governed by type I IFNs (IFNα/β). Our results showed that both wildtype (wt) and the flagellin-deficient L. pneumophila induced IFNβ production in murine bone marrow macrophages (BMMs) dependent on MAVS, IRF3 an…

Schlagworte

Pneumophila Legionella Bacterial Innate Which Infection Replication Immune Mechanisms Against Dependent While Pneumologie