CareLit Fachartikel

DPP-4 inhibitors enhance GIP and attenuate GLP-1 incretin effects during IVGTT in Wistar rats

EJ Freyse, S Berg, P Heinke, KD Kohnert, E Salzsieder · Diabetologie und Stoffwechsel · 2010 · Heft 04

Dokument
1138684
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
EJ Freyse, S Berg, P Heinke, KD Kohnert, E Salzsieder
Ausgabe
Heft 04 / 2010
Seiten
–
Erschienen: 2010-04-21 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0030-1253788

Zusammenfassung

Aims: DPP-4 (dipeptidyl peptidase-4) inhibition has been reported to increase incretin effects of GIP as well as GLP-1 by prolonging their half life. DPP-4 cleaves GIP into dipeptide and the GIP metabolite GIP (3–42), whereas the GLP-1 (7–36) amide is cleaved to GLP-1 (9–36) amide. Based on studies in man, pig and rat, these peptides are involved in various glucoregulatory processes. We have recently developed a test to differentiate the insulinotropic effects of both peptides in rats. In the present study, we compared the insulinotropic effects of the intact GIP and the GLP-1 (7–36) amide during IVGTT following…

Schlagworte

Amide Dipeptidyl Peptidase 4 Blood Glucose Germany Blood Diabetologie und Stoffwechsel