RYGB Surgery in T2DM patients is superior to low calorie diet in improving insulin sensitivity and beta-cell function despite equivalent weight loss

Background: Improved glycemic control after RYGB may be due to changes in food-associated gut hormone signals that occur independent of weight loss. This study investigates whether effects unique to RYGB improve insulin sensitivity and beta cell function independent of simultaneous enteral nutrient passage. Methods: Insulin-supplemented fsIVGTT was performed before and after equivalent weight reduction achieved by either low calorie liquid diet of 800kcal/day (LCD, n=7) or RYGB (n=7) in obese T2DM subjects. MINMOD analysis included glucose effectiveness (Sg), insulin sensitivity (Si), and insulin secretion norma…