The lectin-like domain of thrombomodulin interferes with complement activation and protects against diabetic nephropathy
H Wang, V Ilya, Q Zhou, T He, M Thati, K Shahzad, M Kashif, J Wolter, A Bierhaus, P Nawroth, B Isermann · Diabetologie und Stoffwechsel · 2010 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: Thrombomodulin (TM) is predominantly a vascular endothelial cell plasma membrane glycoprotein that, via distinct structural domains, interacts with multiple ligands, thereby modulating coagulation, fibrinolysis, complement activation, inflammation and cell proliferation. We have previously shown that TM protects against diabetic nephropathy (DN) through activation of protein C(PC), which inhibits glomerular apoptosis. Recent studies showed that TM mediates cytoprotective effects independent of PC activation through it's lectin-like domain (LLD). The LLD directly interferes with complement activatio…
