Amplicon, genomic background and genome instability in heterogeneous MYCN amplified neuroblastoma
D Bogen, IM Ambros, G Amann, E Spuller, J Erichsen, B Brunner, R Ladenstein, T Martinsson, PF Ambros · Klinische Pädiatrie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
In the last decade, around 24% of MYCN amplified (MNA) neuroblastomas (NB) at the CCRI contained a varying number of tumor cells/areas without MNA and were defined as heterogeneously MYCN amplified (hetMNA) according to INRG biology guidelines. For the investigation of the genomic background of hetMNA tumors, up to 4 pieces of the same tumor from 5 patients were analyzed by interphase FISH (I-FISH), MLPA and 250k SNP arrays. MNA was confirmed by at least one method. All tumors showed numeric chromosomal aberrations. Additionally, 3 patients displayed a variety of different segmental chromosomal aberrations (SCA)…
