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Gene expression-based classification improves risk estimation of neuroblastoma patients

A Oberthuer, B Hero, D Juraeva, A Faldum, Y Kahlert, S Asgharzadeh, R Seeger, P Scaruffi, GP Tonini, I Janoueix-Lerosey, O Delattre, G Schleiermacher, J Vandesompele, J Vermeulen, F Speleman, R Noguera, M Piqueras, J Bénard, A Valent, S Avigad, I Yaniv, A Web… · Klinische Pädiatrie · 2010 · Heft 05

Dokument
1138729
CareLit-ID
Jahr
2010
Publikation
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DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
A Oberthuer, B Hero, D Juraeva, A Faldum, Y Kahlert, S Asgharzadeh, R Seeger, P Scaruffi, GP Tonini, I Janoueix-Lerosey, O Delattre, G Schleiermacher, J Vandesompele, J Vermeulen, F Speleman, R Noguera, M Piqueras, J Bénard, A Valent, S Avigad, I Yaniv, A Web…
Ausgabe
Heft 05 / 2010
Seiten
–
Erschienen: 2010-05-07 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0030-1254478

Zusammenfassung

Aim: To evaluate the potential clinical impact of a gene expression-based classifier in neuroblastoma patients. Methods: Microarray analysis was performend on 440 neuroblastoma samples (Germany, n=325; international, n=115). Patients were classified as favorable or unfavorable by a previously defined 144-gene PAM classifier. Classification results were compared with those of prognostic markers and risk estimation strategies. Results: Patients with divergent outcome were reliably distinguished by the PAM classifier in the whole cohort, in the German and the international cohorts separately (OS, p

Schlagworte

Germany Klinische Pädiatrie