CareLit Fachartikel
Evaluation of p53 function in ETV6/RUNX1 positive leukemia
U Kaindl, G Fuka, G Krapf, M Kauer, R Panzer-Gruemayer · Klinische Pädiatrie · 2010 · Heft 05
Dokument
1138730
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
ETV6/RUNX1 (ER) initiates leukemia development but is insufficient to generate overt leukemia by itself. The high number of secondary alterations in these leukemias suggests that DNA damage response is attenuated by the fusion gene, an assumption that is supported by microarray data from primary ALL. Based on its central role as guardian of genomic integrity, we focused on p53 and its regulation by ER. While transient transfection of ER in LNCaP cells resulted in reduced phosphorylation of ATM and its downstream target p53 upon treatment with the DNA-damaging agent VP16, reporter assays indicated that p53 direct…
Schlagworte
These
Leukemias
Cdkn1A
Leukemia
Fusion
Primary
Based
Regulation
Cells
Target
Activated
Further
Klinische Pädiatrie
