Elevated cysteine-protease activity in fecal supernatants of constipation predominant IBS patients: a new factor disrupting colonic epithelial barrier
R Róka, A Annaházi, K Gecse, A Rosztóczy, F Izbéki, T Molnár, O Inczefi, L Ferrier, V Bezirard, H Eutamene, V Theodoru, L Bueno, T Wittmann · Zeitschrift für Gastroenterologie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
Fecal serine-protease activity is elevated in diarrhea type irritable bowel syndrome (IBS-D), and this luminal factor enhances colonic permeability and colorectal sensitivity in mice when infused intracolonically (ic.). Rectal hypersensitivity has been described in all IBS subgroups, including constipation predominant IBS (IBS-C). Other proteases, such as cysteine-proteases (CP) are present in feces, and these proteases were found capable of digesting epithelial tight junction proteins in the human airways. Aims: To compare fecal CP levels in IBS-C and IBS-D patients (pts) with healthy controls, and to test the…
