Intracerebral mass bleeding in a term neonate: Manifestation of hereditary Protein S deficiency with a new mutation in the PROS1 Gene
D Fischer, S Salamat, H Buxmann, A Allendorf, RL Schloesser · Klinische Pädiatrie · 2010 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background: Vitamin K deficiency, birth asphyxia, birth trauma and malformation of blood vessels are the major causes for intracranial bleeding in term neonates and are therefore considered first line in any term neonate with severe haemorrhage. In contrast, the most common manifestation of hereditary prothrombotic disorders during the neonatal period is thrombosis of A. cerebri media or sinus thrombosis. However, the rate of unexplained cases of term newborns with intracerebral mass bleeding remains up to 25%. Case: A primarily healthy male term newborn was admitted to the neonatal intensive care unit on the fo…