The ligands VEGF-A/D and PDGF-A but not the tyrosine kinases receptors are associated with progressed gastic cancer

Aim: We performed this study in order to evaluate the impact of the tyrosine kinases VEGFR1–3, PDGFRα/β and their ligands VEGF-A/C/D and PDGF-A/B on the process of tumor dissemination and survival in gastric cancer. This is the first study anaysing all these parameters in a homogenous patient population. Methods: The expression pattern of VEGF-A/C/D, PDGF-A/B, VEGFR1–3 and PDGFRα/β was analyzed by RT-PCR in 75 samples of human gastric adenocarcinoma and correlated with staging and survival. Results: The expression of the tyrosine kinases VEGFR1, VEGFR2, VEGFR3, PDGFRα and PDGFRβ did not correlate with staging, g…