CareLit Fachartikel
Psychological co-morbidity impairs steroid sensitivity in patients with ulcerative colitis
T Liebregts, B Adam, G Holtmann, G Gerken, G Dobos, J Langhorst · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Dokument
1138956
CareLit-ID
Jahr
2010
Publikation
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Metadaten
DOI
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Zusammenfassung
Aims: Depressive mood and anxiety are discussed to have a negative influence on the course of ulcerative colitis. Psychological stress has been postulated to be associated with greater resistance to molecules that normally terminate the inflammatory cascade. The underlying mechanisms are yet not fully understood. We hypothesized that in patients with ulcerative colitis psychological co-morbidity (UC) at least partly determines susceptibility to steroids. We aimed to explore a correlation between steroid sensitivity [50% inhibitory concentration (IC50) for dexamethasone] of peripheral blood mononuclear cells (PBM…
Schlagworte
Anxiety
Dexamethasone
Depression
Association
Blood
Zeitschrift für Gastroenterologie
