Neuronal autoantibodies excite guinea pig myenteric neurons
Q Li, K Michel, I Demir, F Zeller, S Buhner, G Ceyhan, R De Giorgio, S Gibbons, D Linden, G Farrugia, J Chamberlain, V Lennon, M Schemann · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
The role of IgG in effecting gastrointestinal (G.I.) dysmotility associated with neurologic autoimmunity (idiopathic or paraneoplastic) remains poorly defined. Serum IgG prepared from patients with anti-neuronal nuclear autoantibody type 1 (ANNA-1 [aka anti-Hu], n=7) or ganglionic nicotinic acetylcholine receptor (α3AChR, n=6) autoantibody were tested on myenteric neurons in longitudinal muscle myenteric plexus (LMMP) preparations from the ileum of 38 guinea pigs. IgG prepared from healthy subjects or neurologic patients (n=7) without G.I. symptoms served as controls. Action potential discharges in all neurons o…
