Distinct effect of galectins on the mononuclear phagocyte system

Introduction: Monocytes and macrophages represent the link between the innate and adaptive immune systems and protect the host from the outside world. In inflammatory disorders, however, their activation leads to tissue damage. Galectins have emerged as central regulators of the immune system. Galectins are expressed by intestinal epithelial cells and bind to mucosal T cells. However, if and how they interfere with immune homeostasis by regulating monocyte/macrophage physiology is still unknown. Methods: Monocytes and macrophages were isolated from peripheral blood and mucosa and FACS analysis was used to determ…