CareLit Fachartikel
The role of the vasoactive intestinal peptide receptor VIPR1 polymorphism in gallstone disease: A combined case-control and sib pair analysis
M Krawczyk, M Rusticeanu, F Mihalache, F Grünhage, M Acalovschi, F Lammert · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Dokument
1138961
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Zusammenfassung
Aims: Recently we have identified the p.D19H variation of the ABCG8 cholesterol hemitransporter as the first common genetic determinant for cholelithiasis in humans [1]. On the other hand, dysmotility of gallbladder wall is a well-known risk factor for developing gallstones. Recently, a single nucleotide polymorphism (SNP) of the vasoactive intestinal peptide receptor 1 (VIPR1) gene has been linked to late onset achalasia, a dysmotility disorder of the lower oesophagus [2]. As VIPR1 is expressed in the gallbladder wall as well [3], we now studieded the influence of this VIPR1 SNP on cholelithiasis. Patients and…
Schlagworte
Cholelithiasis
Association
Cholesterol
Population
Database
Allele
Zeitschrift für Gastroenterologie
