CareLit Fachartikel
The common adiponutrin variant p.I148M, a common genetic risk factor for severe forms of NAFLD and ALD, in gallstone patients
M Krawczyk, F Grünhage, F Mihalache, M Acalovschi, F Lammert · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Dokument
1138971
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Recent genome-wide association scans have demonstrated that the common adiponutrin (PNPLA3) coding polymorphism p.I148M increases the risk of developing severe forms of both non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) [1,2]. On the other hand, insulin resistance – known to be linked to the development of non-alcoholic steatohepatitis (NASH) – has been shown to increase the risk of gallstones [3]. In the current study we assessed whether the PNPLA3 p.I148M polymorphism represents a susceptibility factor for gallstone disease. Patients and methods: We collected 229 individuals…
Schlagworte
Association
Allele
Cholecystectomy
Database
Affect
Zeitschrift für Gastroenterologie
