Soluble urokinase plasminogen activator receptor is a marker for severity of liver fibrosis in hepatitis C infection
ML Berres, B Schlosser, T Berg, C Trautwein, HE Wasmuth · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: The plasminogen activator system and its receptors have been implicated in different immune mechanism and serum levels of the soluble urokinase plasminogen activator receptor (suPAR) are elevated in infectious and immune mediated diseases. However, while the importance of the coagulation cascade has been suggested in liver fibrogenesis due to viral heatitis, the role of the fibrinolytic pathway remains unclear. We evaluated the association of serum levels of suPAR with established parameters of liver fibrosis in two independent HCV infected cohorts. Patients and methods: 146 patients with chronic HCV infec…