Silymarin is a potent antiviral drug against HCV in nonresponders to Peginterferon/Ribavirin – Dose finding and viral kinetics studies
TM Scherzer, K Rutter, S Beinhardt, H Kerschner, H Hofer, M Schöniger-Hekele, P Steindl-Munda, P Ferenci · Zeitschrift für Gastroenterologie · 2008 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background: Silibinin (SIL) is the main flavonoid extracted from milk thistle (Silibum marianum G.). By chance we detected that iv. SIL is a potent antiviral compound in patients with chronic hepatitis C not responding to standard antiviral therapy. In this study the optimal dose of SIL was investigated. Furthermore the viral kinetics were studied. For dose finding different dosages of intravenous Silibinin (Legalon Sil®; Madaus, Köln) were given. Patients and Methods: Fifteen nonresponders to full dose peginterferon/ribavirin combination therapy (f: n=1, m: n=14; age: 56±13.6 [mean±SD]; baseline viral load: 3.7…
